Radiogenomics of glioblastoma: a window into its imaging and molecular variability

Learning objectives Gliomas, the most frequent tumours occurring in the CNS, are defined and graded on the basis of histological features to predict prognosis and management. Owing to biological heterogeneity, the histological diagnosis and expected clinical outcome do not match in a significant number of patients. The combination of imaging and gene expression, referred to as “radiogenomics,” has the potential to give insight into tumour biology that would be difficult to acquire from either technique alone.